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KMID : 1123920120260010026
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 1 p.26 ~ p.34
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Effects of Chinemys reevesii on Lipopolysaccaride-indused Inflammatory Reactions
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Baek Young-Mi
Choi Jung-Eun
Lee Cheol-Woo
Jeon Young-Seok
Han Jin-Taek
Jang Sung-Il
Yoo Hwa-Seung
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Abstract
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This study is to investigate the effects of Chinemys reevesii (CR) on allergic inflammation mechanism related chronic dermatitis. To investigate the effects of CR, we study inhibitory effect of CR on the levels of pro-inflammatory cytokines released from RAW 264.7 cell stimulated with lipopolysaccaride (LPS), and EoL-1, THP-1, Jutkat cell stimulated with Dermatophagoides pteronyssinus (DP), and LPS induced acute inflammatory BALB/c mouse model. CR reduced the levels of IL-1β released from RAW 264.7 cell stimulated with LPS at 20 ug/ml, 10 ug/ml concentration. CR significantly reduced the levels of MCP-1 released from EoL-1 cell, IL-6 from THP-1 cell, and IL-4, IL-5, TNF-α from Jutkat cell stimulated with DP at all the concentration. CR significantly reduced the levels of TNF-α, IL-6, IL-1β, in LPS induced inflammatory BALB/c mouse model, in a dose-dependent manner. These results suggested that CR has suppressive effects on pro-inflammatory cytokines in various inflammation related cell lines through the regulation of immune system. CR could be a therapeutic agent for treatment of chronic inflammatory dermatitis in the future.
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KEYWORD
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Chinemys reevesii, anti-inflammation, cytokines, chronic dermatitis
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